Identification of activating enzymes of a novel FBP ase inhibitor prodrug, CS ‐917
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چکیده
منابع مشابه
Identification of activating enzymes of a novel FBPase inhibitor prodrug, CS-917
CS-917 (MB06322) is a selective small compound inhibitor of fructose 1,6-bisphosphatase (FBPase), which is expected to be a novel drug for the treatment of type 2 diabetes by inhibiting gluconeogenesis. CS-917 is a bisamidate prodrug and activation of CS-917 requires a two-step enzyme catalyzed reaction. The first-step enzyme, esterase, catalyzes the conversion of CS-917 into the intermediate f...
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ژورنال
عنوان ژورنال: Pharmacology Research & Perspectives
سال: 2015
ISSN: 2052-1707,2052-1707
DOI: 10.1002/prp2.138